New paper: predicting pyrazinamide resistance Philip Fowler, 20th March 202420th March 2024 This paper has finally been published and you can find it here. It had a slightly tortuous journey from original preprint to updated preprint and now publication. In brief, we use a range of structural, chemical and evolutional features to learn which missense mutations in PncA (encoded by pncA) are associated with resistance to pyrazinamide, one of the four first-line antibiotics used to treat tuberculosis. This research output is designed to be reproducible; you can retrain all machine learning models and replot (nearly) all the figures in the paper using this GitHub repository. Share this:Twitter Related antimicrobial resistance clinical microbiology publication research tuberculosis
tuberculosis Kafka and tuberculosis 21st June 20241st July 2024 To mark the centenary of Franz Kafka’s death from laryngeal tuberculosis at the age of… Share this:Twitter Read More
publication New Publication: Effect of SAO mutation on Band 3 12th January 201729th September 2018 There is a lovely story behind this paper just published earlier this week in Biochemistry…. Share this:Twitter Read More
antimicrobial resistance New software: gemucator 4th September 20184th September 2018 Short for “Genbank Mutation Locator”. A simple Python3 package that if you pass it a… Share this:Twitter Read More