New paper: predicting pyrazinamide resistance Philip Fowler, 20th March 202420th March 2024 This paper has finally been published and you can find it here. It had a slightly tortuous journey from original preprint to updated preprint and now publication. In brief, we use a range of structural, chemical and evolutional features to learn which missense mutations in PncA (encoded by pncA) are associated with resistance to pyrazinamide, one of the four first-line antibiotics used to treat tuberculosis. This research output is designed to be reproducible; you can retrain all machine learning models and replot (nearly) all the figures in the paper using this GitHub repository. Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance clinical microbiology publication research tuberculosis
antimicrobial resistance New Publication: Predicting whether mutations confer resistance to an antibiotic 5th January 201829th September 2018 Due to the rise of antibiotic resistance, it is increasingly important that your clinician knows… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
publication New Publication: Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels 31st October 2013 Can we predict the conductance of a potassium ion channel from an experimental structure? In this… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance Updating the Grammar for Antimicrobial Resistance Catalogues 18th July 202418th July 2024 This blog updates an old (and now out of date) post describing the grammar we’ve… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More