New paper: predicting pyrazinamide resistance Philip Fowler, 20th March 202420th March 2024 This paper has finally been published and you can find it here. It had a slightly tortuous journey from original preprint to updated preprint and now publication. In brief, we use a range of structural, chemical and evolutional features to learn which missense mutations in PncA (encoded by pncA) are associated with resistance to pyrazinamide, one of the four first-line antibiotics used to treat tuberculosis. This research output is designed to be reproducible; you can retrain all machine learning models and replot (nearly) all the figures in the paper using this GitHub repository. Share this:TwitterBlueskyEmailLinkedInMastodon Related antimicrobial resistance clinical microbiology publication research tuberculosis
GPAS stopover on the ORACLE road trip 1st February 20221st February 2022 You can listen to Philip Fowler talk about the Global Pathogen Analysis System (GPAS) as… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
publication New Publication: Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY 8th November 2013 In this paper we examine how the lactose permease, LacY, changes its structure to shuttle… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
publication New Publication: NRas slows the rate at which a model lipid bilayer phase separates 13th June 2014 Here we examine by computer simulation what effect adding a small cell-signalling protein does… Share this:TwitterBlueskyEmailLinkedInMastodon Read More