New Publication: Energetics of Multi-Ion Conduction Pathways in Potassium Ion Channels Philip Fowler, 31st October 2013 0 shares Can we predict the conductance of a potassium ion channel from an experimental structure? In this paper we examine the kinetic barriers experienced by potassium ions (and waters) as they move through the narrowest part of two different potassium ion channels. We examine the reproducibility of our results and test the sensitivity of the approach to changes in the method. We conclude that we are currently unable to accurately calculate the kinetic barriers to conduction for potassium channels and that other channels (such as sodium channels) may be more amenable to this approach. This article is published in the Journal of Chemical Theory and Computation and is free to download (open access). It carries out the preparatory work necessary for a second paper on how potassium ions and water molecules move through the selectivity filter of a voltage-gated potassium ion channel. Share this:Twitter Related publication research
publication New Publication: State-Dependent Network Connectivity Determines Gating in a K+ Channel 27th June 2014 In an earlier paper we showed that the closed state of Kir1.1, a important potassium… Share this:Twitter Read More
antimicrobial resistance New publication: Assessing Drug Susceptibility in Tuberculosis 28th September 201829th September 2018 A paper was published in the New England Journal of Medicine earlier this week by… Share this:Twitter Read More
antimicrobial resistance New preprint: Predicting antibiotic resistance in complex protein targets 4th January 20224th January 2022 In this preprint, which Alice has been working on for several years, we show how… Share this:Twitter Read More