I am studying for a DPhil in Clinical Medicine, supervised by Philip Fowler and Sarah Walker, with funding from the Nuffield Department of Medicine. I previously undertook both Masters and undergraduate degrees in Biochemistry at the university of York. My interests are in protein structure and antibiotic resistance in M. tuberculosis.
Oliver did his first rotation in the group from Jan-Mar 2017 as part of his Interdisciplinary Biosciences DTP DPhil before working in Simon Newstead’s group in Biochemistry learning structural biology techniques. He is supervised by myself and Simon and is working on M. tuberculosis efflux pumps and drug targets until June 2021.
Dylan joined the group in October 2020 and developing machine-learning models that use structural and chemical information to predict resistance to a first-line anti-TB compound.
I am a University Research Lecturer working in the Modernising Medical Microbiology group which is part of Experimental Medicine in the Nuffield Department of Medicine at the University of Oxford. I’m based at the John Radcliffe Hospital in Oxford, having moved here in March 2016 from the Department of Biochemistry. For more information, click the links in the menu above or check out my departmental webpages.
Alexander studied for his Part II research project Oct 2019-May 2020 and studied how various mutations in Penicillin Binding Proteins from Neisseria gonorrhoeae confer resistance to beta-lactam antibiotics. He collaborated with Professor Chris Dowson’s group at Warwick University.
Josh was a Rhodes Scholar who I supervised, along with Derrick Crook, for his Masters degree that he successfully defended in June 2019. He applied different machine-learning approaches to predicting the effect of single nucleotide polymorphisms in the pncA gene on the action of pyrazinamide, one of the four first-line anti-tubercular compounds. A paper is under review and you can read the preprint here.
Dom did his research project for his Biochemistry undergraduate degree in the group between September 2018 and March 2019 and worked on determining how the free energy of binding of isoniazid to its target, KatG, is influenced by mutations in M. tuberculosis, using molecular dynamics simulations. He is now studying for a PhD at UCL in the group of Francesco Gervasio.
Mark did his fourth year (Part II) research project for his biochemistry undergraduate degree jointly in my group and Simon Newstead’s in Biochemistry working on solving the structures of several M.tuberculosis proteins.
Firdaus studied for his DPhil, Improving Oral Drug Delivery: Computational Studies of Proton Dependent Oligopeptide Transporters under the supervision of PWF. He published two key papers which you can read about here and here. He worked with Prof Syma Khalid at Southampton University for a few years and is now in the lab of Dr Peter Bond at the A*STAR Bioinformatics Institute in Singapore.