New paper: predicting pyrazinamide resistance Philip Fowler, 20th March 202420th March 2024 This paper has finally been published and you can find it here. It had a slightly tortuous journey from original preprint to updated preprint and now publication. In brief, we use a range of structural, chemical and evolutional features to learn which missense mutations in PncA (encoded by pncA) are associated with resistance to pyrazinamide, one of the four first-line antibiotics used to treat tuberculosis. This research output is designed to be reproducible; you can retrain all machine learning models and replot (nearly) all the figures in the paper using this GitHub repository. Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance clinical microbiology publication research tuberculosis
antimicrobial resistance New publication: Automated detection of bacterial growth on 96-well plates for high-throughput drug susceptibility testing of M. tuberculosis 26th October 2018 In this Microbiology paper we show how a Python package, called the Automated Mycobacterial Detection Growth… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance New paper: how well can we predict AMR in tuberculosis samples? 16th December 202516th December 2025 This paper just published in Microbial Genomics examines how well our software tool, gnomonicus, predicts… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance BashTheBug reaches one million classifications 4th October 20184th October 2018 BashTheBug, a citizen science project I run that is helping us measure how different… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More