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Fowler Lab
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Predicting antimicrobial resistance

New publication: Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

Philip Fowler, 9th March 202016th March 2020

Although the population structure M. tuberculosis is clonal, one must be careful when inferring the effect of individual mutations on the effect of an antibiotic. Purely because a mutation appears to define a phylogeny does not mean it has no effect on the minimum inhibitory concentration.

Read more here (Open Access).

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clinical microbiology

ESM Annual Congress 2026

26th June 202626th June 2026

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antimicrobial resistance

BashTheBug Coordinator post advertised

15th November 2019

We are advertising for a Part-time Citizen Science Project Co-ordinator to come and work with…

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New publication: Predicting antibiotic resistance in complex protein targets using alchemical free energy methods

26th August 202224th October 2022

In this paper, Alice Brankin calculates how different mutations in the DNA gyrase affect the…

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