publication research

New Publication: Protein crowding affects the organisation of ion channels

Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes

It is difficult to look at the dynamic spatial organisation of ion channels in cell membranes, but this is something coarse-grained molecular dynamics simulations can offer insights. This work, led by Anna Duncan, shows how altering the lipid composition of the membrane changes the large-scale organisation of the Kir2.2 channels. Building on some previous work, we also show how the membrane properties, such as stiffness, are also altered. The latter relies on some python code that you can download from GitHub. The paper is free to download.

By Philip Fowler

Philip W Fowler is a computational biophysicist studying antimicrobial resistance working at the John Radcliffe Hospital in Oxford.

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