The CRyPTIC project collecting over 20,000 clinical samples of TB and for each, sequencing its genome and testing its susceptibility to 13 different antibiotics. A lovely unintended consequence of compiling such a large high-quality dataset is that CRyPTIC was invited to form part of the team that collected data and compiled the first catalogue of resistance-conferring mutations for M. tuberculosis complex published by the World Health Organization in June 2021.
This paper, that is just out in Lancet Microbe, describes in more detail the analysis necessary to build the catalogue.
