New Publication: Proteins Alter the Stiffness of Membranes Philip Fowler, 23rd September 201629th September 2018 0 shares Although there have been many studies of proteins whose primary function is to ‘sculpt’ the surface of membranes e.g. BAR domains, there have been very few investigations of what effect regular membrane proteins have on the stiffness of membranes. Here we show via very large simulations, using the MARTINI coarse-grained forcefield, that ‘regular’ integral membrane proteins, such as an ion channel or a beta-barrel, reduce the stiffness of the membrane, leading to larger fluctuations. The systems studied push the boundaries of what is currently achievable with biomolecular simulation, containing around 50,000 lipids and 100 proteins. We had access to the French supercomputer CURIE, through the EU PRACE network, for this work. This is the second in a set of three papers that bring my research on cell signalling and membranes in the SBCB group within the Department of Biochemistry to a close and is available to download here. Share this:Twitter Related publication research
antimicrobial resistance New paper: detecting compensatory mutations in the RNAP of M. tuberculosis 5th February 20245th February 2024 In this paper, by examining testing the association between mutations known to be associate with… Share this:Twitter Read More
clinical microbiology New publication: Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers 13th January 202113th January 2021 A second Covid-19 publication I’m proud to be (a small) part of has recently published… Share this:Twitter Read More
antimicrobial resistance New Publication: Predicting whether mutations confer resistance to an antibiotic 5th January 201829th September 2018 Due to the rise of antibiotic resistance, it is increasingly important that your clinician knows… Share this:Twitter Read More