New preprint: comparing different genetics analysis pipelines for tuberculosis Philip Fowler, 13th January 202513th January 2025 Ruan Spies has done a careful systematic comparison of the current genetics pipelines that purport to take raw genetic reads from a clinical sample containing M. tuberculosis (or Mycobacteria generally) and process them to produce a putative genome from which an antibiogram can be predicted. He couldn’t get some of the pipelines to work but of the others, with a few exceptions, AMR prediction performance was often similar. The non-functional features of EIT Pathogena stand-out; these are things like resilience, ease-of-use, speed and security. You can read about it here. Share this:TwitterBlueskyEmailLinkedInMastodon Related antimicrobial resistance clinical microbiology gpas publication research tuberculosis
citizen science Automated detection of bacterial growth on 96-well plates (AMyGDA) 11th December 20175th August 2018 I am involved in an international collaboration, the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
antimicrobial resistance New publication: how quickly can be calculate the effect of a mutation on an antibiotic? 20th November 202020th November 2020 The idea for this paper arose during talking over coffee at the BioExcel Alchemical Free… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
publication New Publication: State-Dependent Network Connectivity Determines Gating in a K+ Channel 27th June 2014 In an earlier paper we showed that the closed state of Kir1.1, a important potassium… Share this:TwitterBlueskyEmailLinkedInMastodon Read More