New Publication: The Extra-Cellular Domain of PepT1 and PepT2 Philip Fowler, 2nd November 2015 0 shares PepT1 is a nutrient transporter found in the cells that line your small intestine. It is not only responsible for the uptake of di- and tai-peptides, and therefore much of your dietary proteins, but also the uptake of most β-lactam antibiotics. This serendipity ensures that we can take (many of) these important drugs orally. Our ultimate goal is to develop the capability to predict modifications to drug scaffolds that will improve or enable their uptake by PepT1, thereby improving their oral bioavailability. In Structure we report the structures of the extra-cellular domains (ECDs) of PepT1 and PepT2. This is an important milestone on the road to elucidating a structure of PepT1 and allows us to propose the first full-length structural model of PepT1 (see above). Intriguingly, the data also suggests that the ECD also interacts with trypsin, thereby increasing the local concentration of peptides around the transporter, improving its efficiency. Share this:Twitter Related publication research
antimicrobial resistance New paper: detecting compensatory mutations in the RNAP of M. tuberculosis 5th February 20245th February 2024 In this paper, by examining testing the association between mutations known to be associate with… Share this:Twitter Read More
antimicrobial resistance New print: Epidemiological cutoff values for a 96-well broth microdilution plate for M. tuberculosis 5th March 202122nd March 2021 In this preprint, the CRyPTIC project proposes the maximum value of minimum inhibitory concentration (MIC)… Share this:Twitter Read More
This blog… 31st October 2012 …is where I shall put thoughts that at least might be of interest to other… Share this:Twitter Read More