New Publication: Structure of MmpL3 Philip Fowler, 21st July 202121st July 2021 Oliver Adams successfully elucidated the structure of the M. tuberculosis MmpL3 membrane transporter using cryo-EM and this has recently been published online in Structure. This was the main aim of his PhD studies in Simon Newstead‘s group in the Department of Biochemistry here in Oxford. It is an important protein structure since although other MmpL3 structures have been solved, this is the first one from M. tuberculosis and, as the only essential member of the MmpL family, is targeted by a number of drugs under development, for example SQ109 which is currently in Phase 2 clinical trials. Being able to see how the drug interacts with the protein can help us understand a variety of effects, from binding to resistance. Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance publication research tuberculosis
New preprint: Including minor alleles improves fluoroquinolone resistance prediction 10th November 202217th November 2022 Fluoroquinolones are used to treat both normal and drug resistant tuberculosis and therefore being able… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance Can medical microbiology become a big data science? Lessons from CRyPTIC 11th March 202511th March 2025 The CRyPTIC project ran from 2017 to around 2022 and in that time collected over… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance Successful NIHR grant 29th June 20185th August 2018 Last year I coordinated a bid to the NIHR for capital to improve our research… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More