New Publication: Structure of MmpL3 Philip Fowler, 21st July 202121st July 2021 Oliver Adams successfully elucidated the structure of the M. tuberculosis MmpL3 membrane transporter using cryo-EM and this has recently been published online in Structure. This was the main aim of his PhD studies in Simon Newstead‘s group in the Department of Biochemistry here in Oxford. It is an important protein structure since although other MmpL3 structures have been solved, this is the first one from M. tuberculosis and, as the only essential member of the MmpL family, is targeted by a number of drugs under development, for example SQ109 which is currently in Phase 2 clinical trials. Being able to see how the drug interacts with the protein can help us understand a variety of effects, from binding to resistance. Share this:TwitterBlueskyEmailLinkedInMastodon Related antimicrobial resistance publication research tuberculosis
antimicrobial resistance BioExcel Alchemical Free Energy workshop 17th June 2019 Last month I was invited to give a talk on using alchemical free energy methods… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
antimicrobial resistance New publication: Reconciling the potentially irreconcilable? Genotypic and phenotypic amoxicillin-clavulanate resistance in Escherichia coli. 30th March 202022nd August 2020 Clinical microbiology often assumes a sample is resistant or susceptible. Making such a classification relies… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
citizen science Automated detection of bacterial growth on 96-well plates (AMyGDA) 11th December 20175th August 2018 I am involved in an international collaboration, the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium… Share this:TwitterBlueskyEmailLinkedInMastodon Read More