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Fowler Lab
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Predicting antibiotic resistance de novo

New print: Epidemiological cutoff values for a 96-well broth microdilution plate for M. tuberculosis

Philip Fowler, 5th March 202122nd March 2021

In this preprint, the CRyPTIC project proposes the maximum value of minimum inhibitory concentration (MIC) for 13 different anti-TB drugs below which a sample can be considered to be ‘genotypically wild-type’.

It is necessary to establish these values, called epidemiological cutoff values (ECOFFs or ECVs), so that the MICs measured can be converted into binary (resistant/susceptible), or in the case of three drugs ternary (resistant/intermediate/susceptible), predictions.

The preprint draws on 20,637 clinical isolates collected by 14 CRyPTIC laboratories based in 11 countries on five continents.

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