New print: Epidemiological cutoff values for a 96-well broth microdilution plate for M. tuberculosis Philip Fowler, 5th March 202122nd March 2021 0 shares In this preprint, the CRyPTIC project proposes the maximum value of minimum inhibitory concentration (MIC) for 13 different anti-TB drugs below which a sample can be considered to be ‘genotypically wild-type’. It is necessary to establish these values, called epidemiological cutoff values (ECOFFs or ECVs), so that the MICs measured can be converted into binary (resistant/susceptible), or in the case of three drugs ternary (resistant/intermediate/susceptible), predictions. The preprint draws on 20,637 clinical isolates collected by 14 CRyPTIC laboratories based in 11 countries on five continents. Share this:Twitter Related antimicrobial resistance clinical microbiology publication research tuberculosis
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