New publication: determining novel mechanisms of bedaquiline resistance Philip Fowler, 30th March 20235th April 2023 1 shares A new paper with Lindsay Sonnenkalb as first-author has just been published in The Lancet Microbe. It is a collaboration between a number of groups, led by Stefan Niemann and in it we evolved resistance to bedaquiline in vitro. Sequencing revealed 265 genetic variants with 250 affecting Rv0678, which is the transcription regulator of mmpL5, an efflux pump. These variants included a number of novel mutations and, interestingly, a large scale rearrangement of Rv0678 which was confirmed with PacBio sequencing. The article is free to read and you can access it here. Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance clinical microbiology publication research tuberculosis
clinical microbiology New preprint: processing SARS-CoV-2 genetics in the cloud 31st January 202431st January 2024 In this preprint, we describe how in July 2022 for two weeks seven sites in… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance New preprint: rapid prediction of AMR by free energy methods 15th January 202015th January 2020 The story behind this preprint goes back to the workshop on free energy methods run… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
meetings ESM Annual Congress 2025 25th June 20251st July 2025 Several of us attended the 45th Annual Congress of the European Society of Mycobacteriology in… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More