New publication: determining novel mechanisms of bedaquiline resistance Philip Fowler, 30th March 20235th April 2023 1 shares A new paper with Lindsay Sonnenkalb as first-author has just been published in The Lancet Microbe. It is a collaboration between a number of groups, led by Stefan Niemann and in it we evolved resistance to bedaquiline in vitro. Sequencing revealed 265 genetic variants with 250 affecting Rv0678, which is the transcription regulator of mmpL5, an efflux pump. These variants included a number of novel mutations and, interestingly, a large scale rearrangement of Rv0678 which was confirmed with PacBio sequencing. The article is free to read and you can access it here. Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance clinical microbiology publication research tuberculosis
clinical microbiology New preprint: processing 3.9 million SARS-CoV-2 samples to make a consistent phylogenetic tree 7th May 20247th May 2024 Martin Hunt, Zam Iqbal and lots of others have written an epic preprint where they… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance AMyGDA now available from GitHub 27th January 202027th January 2020 AMyGDA is a python module that analyses photographs of 96-well plates and, by examining each… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
New preprint: a deep learning model that can read 96-well broth micro dilution plates 23rd February 202523rd February 2025 The CRyPTIC project used bespoke 96-well broth microdilution plates to measure the minimum inhibitory concentrations… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More