New publication: WHO catalogue of Mycobacterium tuberculosis resistant mutations Philip Fowler, 28th March 202228th March 2022 The CRyPTIC project collecting over 20,000 clinical samples of TB and for each, sequencing its genome and testing its susceptibility to 13 different antibiotics. A lovely unintended consequence of compiling such a large high-quality dataset is that CRyPTIC was invited to form part of the team that collected data and compiled the first catalogue of resistance-conferring mutations for M. tuberculosis complex published by the World Health Organization in June 2021. This paper, that is just out in Lancet Microbe, describes in more detail the analysis necessary to build the catalogue. Share this:TwitterBlueskyEmailLinkedInMastodon Related antimicrobial resistance research tuberculosis
New preprint: validating antibiotic resistance prediction in our Myco pipeline 9th November 202413th January 2025 Over the last 18 months or so we’ve been designing, coding and testing a Mycobacterial… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
New grant: Ox4TB 17th March 202517th March 2025 Very pleased to announce that I am a co-investigator on the recently announced Oxford4TB project… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
antimicrobial resistance New preprint: Predicting pyrazinamide resistance by machine learning 29th April 201929th April 2019 Usually, the protein that an antibiotic binds is essential for bacterial survival, which is how… Share this:TwitterBlueskyEmailLinkedInMastodon Read More