I’ve moved… Philip Fowler, 14th March 20165th August 2018 Today is my first day as a Senior Researcher in Modernising Medical Microbiology in the Nuffield Department of Medicine at the University of Oxford. Practically I’ll be based at the John Radcliffe Hospital in Oxford. I was a Postdoctoral Researcher in the SBCB Unit at the Department of Biochemistry for ten years, working with Professor Mark Sansom. During that time I used computer simulation to study the function of a variety of membrane proteins, focussing mainly on cell signalling, transporters and ion channels. Now I will be leading efforts to predict whether novel bacterial mutations lead to antibiotic resistance (or not). The key idea is to examine the effect of each mutation on the binding of the antibiotic to its target protein. This boils down to calculating how the binding free energy changes when you make the mutation — something that alchemical free energy methods, such as thermodynamic integration is well-suited to. More soon. Share this:TwitterBlueskyEmailLinkedInMastodon Related antimicrobial resistance clinical microbiology miscellaneous tuberculosis
antimicrobial resistance New software: pygsi 31st August 2018 Whenever a paper involving sequencing the genome of bacteria (or other species for that matter),… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
antimicrobial resistance GARC: A Grammar for Antimicrobial Resistance Catalogues 25th November 201817th November 2020 During the CRyPTIC project it has become obvious that we need a grammar to describe… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
clinical microbiology New preprint: processing 3.9 million SARS-CoV-2 samples to make a consistent phylogenetic tree 7th May 20247th May 2024 Martin Hunt, Zam Iqbal and lots of others have written an epic preprint where they… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
Congratulations, Phil! Cool to use statistical physics, computer simulations and structural biology to combat the pressing problem of bacterial resistance to antimicrobials. That’s a fight we (as a civilization) can’t afford to loose. Reply