I’ve moved… Philip Fowler, 14th March 20165th August 2018 Today is my first day as a Senior Researcher in Modernising Medical Microbiology in the Nuffield Department of Medicine at the University of Oxford. Practically I’ll be based at the John Radcliffe Hospital in Oxford. I was a Postdoctoral Researcher in the SBCB Unit at the Department of Biochemistry for ten years, working with Professor Mark Sansom. During that time I used computer simulation to study the function of a variety of membrane proteins, focussing mainly on cell signalling, transporters and ion channels. Now I will be leading efforts to predict whether novel bacterial mutations lead to antibiotic resistance (or not). The key idea is to examine the effect of each mutation on the binding of the antibiotic to its target protein. This boils down to calculating how the binding free energy changes when you make the mutation — something that alchemical free energy methods, such as thermodynamic integration is well-suited to. More soon. Share this:Twitter Related antimicrobial resistance clinical microbiology miscellaneous tuberculosis
tuberculosis Kafka and tuberculosis 21st June 20241st July 2024 To mark the centenary of Franz Kafka’s death from laryngeal tuberculosis at the age of… Share this:Twitter Read More
antimicrobial resistance New Publication: Predicting whether mutations confer resistance to an antibiotic 5th January 201829th September 2018 Due to the rise of antibiotic resistance, it is increasingly important that your clinician knows… Share this:Twitter Read More
antimicrobial resistance BashTheBug at the Science Museum 29th March 20175th August 2018 A group of us from Modernising Medical Microbiology went to the Science Museum in London… Share this:Twitter Read More
Congratulations, Phil! Cool to use statistical physics, computer simulations and structural biology to combat the pressing problem of bacterial resistance to antimicrobials. That’s a fight we (as a civilization) can’t afford to loose. Reply