New Publication: NRas slows the rate at which a model lipid bilayer phase separates Philip Fowler, 13th June 2014 Here we examine by computer simulation what effect adding a small cell-signalling protein does to a model ternary lipid mixture that has been shown before to phase separate. This paper was presented at the 169th Faraday Discussion meeting in Nottingham in May 2014, the theme of which was Molecular simulations and visualization. We followed the progress of the phase separation of the lipid bilayer by measuring the length of the interface using an edge detection algorithm from image processing. An example python script can be downloaded here. We found that the protein, NRas, indeed slows down the rate at which the bilayer phase separates. The protein also tends to localise to the interface between the domains which is consistent with it acting to reduce the line tension between the phases. The questions asked during the discussion (and my answers) will be posted on the journal’s website soon. I’ll update this post when that happens. This paper is open access so is free to download. Share this:TwitterBlueskyEmailLinkedInMastodon Related publication
antimicrobial resistance New print: Epidemiological cutoff values for a 96-well broth microdilution plate for M. tuberculosis 5th March 202122nd March 2021 In this preprint, the CRyPTIC project proposes the maximum value of minimum inhibitory concentration (MIC)… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
antimicrobial resistance New paper: quantitative measurement of effect of mutations on antibiotics in M. tuberculosis 15th January 202415th January 2024 The CRyPTIC project played a major role in the release by the WHO of their… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
publication New Publication: Effect of SAO mutation on Band 3 12th January 201729th September 2018 There is a lovely story behind this paper just published earlier this week in Biochemistry…. Share this:TwitterBlueskyEmailLinkedInMastodon Read More