New Publication: Detailed examination of a single conduction event in a potassium channel. Philip Fowler, 15th October 2013 What can we learn using computational methods about how potassium ions and water molecules move through the narrowest part of a potassium channel? In this paper, we calculate the average force experienced by three potassium ions as they move through the selectivity filter of a voltage-gated potassium channel. This allows us to identify the most probably mechanism, which includes two “knock-on” events, just like a Newton’s cradle. By examining the behaviour of the conducting waters and the protein in detail we can see how the waters rotate to coordinate one or other of the conducting potassium ions, and even get squeezed between two potassium ions during a knock-on event. We also see how the coordination number of each potassium ion changes. This article is published in the Journal of Physical Chemistry Letters and is free to download (open access). There is an accompanying paper that is published in the Journal of Chemical Theory and Computation. Share this:TwitterBlueskyEmailLinkedInMastodon Related publication research papersresearch
antimicrobial resistance Updated preprint: predicting pyrazinamide resistance 21st November 20238th December 2023 This study was performed by Josh Carter back in 2019 and we uploaded a preprint… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
antimicrobial resistance New publication: Assessing Drug Susceptibility in Tuberculosis 28th September 201829th September 2018 A paper was published in the New England Journal of Medicine earlier this week by… Share this:TwitterBlueskyEmailLinkedInMastodon Read More
New preprint: Including minor alleles improves fluoroquinolone resistance prediction 10th November 202217th November 2022 Fluoroquinolones are used to treat both normal and drug resistant tuberculosis and therefore being able… Share this:TwitterBlueskyEmailLinkedInMastodon Read More