New preprint: ONT sequencing is comparable to Illumina sequencing for M. tuberculosis Philip Fowler, 9th April 20269th April 2026 In this preprint, we compare the differences when Mycobacterial samples are sequenced with either long- or short-read sequencing and show that long-read sequencing (as exemplified by Oxford Nanopore Technologies) is now comparable to short-read sequencing (e.g. Illumina). As we are focussed on clinical microbiological outputs, we compare the ability of both approaches to resolve the species and, if M. tuberculosis, to predict to which antibiotics the infection will be susceptible. Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Related publication tuberculosis
publication New Publication: State-Dependent Network Connectivity Determines Gating in a K+ Channel 27th June 2014 In an earlier paper we showed that the closed state of Kir1.1, a important potassium… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
New publication: determining novel mechanisms of bedaquiline resistance 30th March 20235th April 2023 A new paper with Lindsay Sonnenkalb as first-author has just been published in The Lancet… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More
New preprint: validating antibiotic resistance prediction in our Myco pipeline 9th November 202413th January 2025 Over the last 18 months or so we’ve been designing, coding and testing a Mycobacterial… Share this: Share on X (Opens in new window) X Share on Bluesky (Opens in new window) Bluesky Email a link to a friend (Opens in new window) Email Share on LinkedIn (Opens in new window) LinkedIn Share on Mastodon (Opens in new window) Mastodon Read More