New publication: Predicting resistance is (not) futile Philip Fowler, 21st August 201921st August 2019 Our “First Reactions” article has been published in ACS Central Science. We discuss the paper, Predicting Kinase Inhibitor Resistance: Physics-Based and Data-Driven Approaches, by Matteo Aldeghi, Vytautas Gapsys and Bert de Groot, which is in the same issue of the journal. Aldeghi et al. apply a series of methods to try and predict the effect of individual mutations on how well tyrosine kinase inhibitors bind to the Abl kinase. These methods include not only alchemical free energy methods but also machine learning. You can read it here. Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance molecular dynamics publication
antimicrobial resistance FowlerLab at ESM 2024 1st July 20241st July 2024 Three of us (Dylan Adlard, Dylan Dissanayake and Philip Fowler) attended the 44th Congress of… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance New paper: Quantitative drug susceptibility testing for M. tuberculosis using unassembled sequencing data and machine learning 14th August 202414th August 2024 This is the last paper from the initial set of CRyPTIC publications following the project’s… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance New software: pygsi 31st August 2018 Whenever a paper involving sequencing the genome of bacteria (or other species for that matter),… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More