Successful NIHR grant Philip Fowler, 29th June 20185th August 2018 Last year I coordinated a bid to the NIHR for capital to improve our research capacity to study antimicrobial resistance (AMR) at the Oxford Biomedical Research Centre. We were successful and were awarded £1.8 million to fund several different activities, including developing vaccines to prevent the spread of AMR. Previously in the John Radcliffe hospital Clinical Microbiology had one small second-generation genetic sequencer; now as a result of the grant we have a second, but more crucially, two very high-throughput third-generation genetic sequencers. These are GridIONs from Oxford Nanopore and sequence DNA in a completely different way that could revolutionise the use of genetics in Clinical Microbiology. Grants like this all too-often often focus on the experimental equipment at the expense of the compute and storage you need to analyse and store the data. We were fortunate to secure funds to provide a small processing cluster in the room next to the sequencing facility in addition to much larger storage and compute at the Big Data Institute, part of which my group will be able to use to continue to develop methods for de novo prediction of the effect of individual protein mutations on the actions of antibiotics. Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Related antimicrobial resistance clinical microbiology grants research
antimicrobial resistance CRyPTIC datasets available through new website 25th June 20257th July 2025 The CRyPTIC project ran from 2016 to 2022 and collected >20,000 clinical samples from patients… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance New publication: Validating a bespoke 96-well plate for high-throughput drug susceptibility testing of M. tuberculosis 28th August 201829th September 2018 This paper, published in Antimicrobial Agents and Chemotherapy, determines the reproducibility and accuracy of minimum… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More
antimicrobial resistance Accelerating Oxford Nanopore basecalling 26th January 20175th August 2018 It looks innocuous sitting on the desk, an Oxford Nanopore MinION, but it can produce… Share this: Click to share on X (Opens in new window) X Click to share on Bluesky (Opens in new window) Bluesky Click to email a link to a friend (Opens in new window) Email Click to share on LinkedIn (Opens in new window) LinkedIn Click to share on Mastodon (Opens in new window) Mastodon Read More