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Philip Fowler appointed as Associate Professor

More good news for the group! Philip was awarded an Associate Professorship by the Nuffield Department of Medicine along with two other researchers.

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antimicrobial resistance group meetings tuberculosis

Viki Brunner wins poster prize

The whole group attended the first INEOS Oxford Institute meeting on Multidisciplinary Approaches to AMR on Tuesday 22 November 2022. Great to hear how different research groups around Oxford (and elsewhere) are helping to tackle AMR. Best of all though, Viki Brunner won one of the poster prizes for her poster on Compensatory mutations in […]

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antimicrobial resistance clinical microbiology publication research tuberculosis

New preprint: Including minor alleles improves fluoroquinolone resistance prediction

Fluoroquinolones are used to treat both normal and drug resistant tuberculosis and therefore being able to work out if an infection is resistant or not to fluoroquinolones is very important. Sequencing the genome of an infection is increasingly used to rapidly return which antibiotics could be used to treat a patient with tuberculosis. Genetics-based approaches […]

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antimicrobial resistance computing molecular dynamics tuberculosis

New publication: Predicting antibiotic resistance in complex protein targets using alchemical free energy methods

In this paper, Alice Brankin calculates how different mutations in the DNA gyrase affect the binding of an antibiotic, moxifloxacin, and thereby potentially whether those mutations confer resistance or not. She calculates the relative binding free energy using thermodynamic integration, a method that is derived from classical statistical mechanics. To accompany these results, Philip Fowler, […]

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antimicrobial resistance clinical microbiology tuberculosis

New publication: CRyPTIC Data Compendium

The large and comprehensive dataset of clinical tuberculosis isolates collected by the CRyPTIC project is described in detail by this paper, just published in PLoS Biology. Each isolate was whole genome sequenced and had its minimum inhibitory concentration to 13 different antibiotics measured using a bespoke 96-well broth microdilution plate. Alice Brankin, along with Kerri […]

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antimicrobial resistance clinical microbiology tuberculosis

New publication: CRyPTIC GWAS of antitubercular resistance

Since the primary goal of CRyPTIC was to map the genetic variants in M. tuberculosis associated with resistance to different antibiotics, this genome-wide association study is one of the key research outputs of the project. It brings together all the samples with genetic and drug susceptibility testing (DST) data and therefore relies on all the […]