Last year, the CRyPTIC Consortium published a detailed study establishing epidemiological cutoff values (ECOFFs or ECVs) so that it could binarise the minimum inhibitory concentrations it measured for 13 antibiotics for over 15,000 samples of M. tuberculosis collected worldwide.
This paper attracted two letters to the editor of the journal, Eur Resp J, which you can read here and here. We wrote a careful reply which is here.
