New Publication: Protein crowding affects the organisation of ion channels Philip Fowler, 3rd December 201729th September 2018 0 shares Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes It is difficult to look at the dynamic spatial organisation of ion channels in cell membranes, but this is something coarse-grained molecular dynamics simulations can offer insights. This work, led by Anna Duncan, shows how altering the lipid composition of the membrane changes the large-scale organisation of the Kir2.2 channels. Building on some previous work, we also show how the membrane properties, such as stiffness, are also altered. The latter relies on some python code that you can download from GitHub. The paper is free to download. Share this:Twitter Related publication research
publication New Publication: NRas slows the rate at which a model lipid bilayer phase separates 13th June 2014 Here we examine by computer simulation what effect adding a small cell-signalling protein does… Share this:Twitter Read More
antimicrobial resistance New Publication: Structure of MmpL3 21st July 202121st July 2021 Oliver Adams successfully elucidated the structure of the M. tuberculosis MmpL3 membrane transporter using cryo-EM… Share this:Twitter Read More
antimicrobial resistance New Publication: Predicting whether mutations confer resistance to an antibiotic 5th January 201829th September 2018 Due to the rise of antibiotic resistance, it is increasingly important that your clinician knows… Share this:Twitter Read More