Cheltenham Science Festival

A bit over a week ago I helped run the Modernising Medical Microbiology stall at the Cheltenham Science Festival. This was my first time helping explain about antibiotic resistance to, well, anyone and everyone. As I come from a molecular background and we didn’t have any information about protein structure, I thought I’d put together something explaining how mutations in the bacterial genome can prevent an antibiotic from binding to its target protein, thereby giving rise to resistance.How protein mutations can give rise to antibiotic resistance

The chosen medium for this was Lego (DUPLO to be precise.). I wanted to be able to let younger children play with the DUPLO and then I could use the LEGO models to show it to older children (and adults). This is shown above.

Then, for older children, we could move onto looking at a real protein structure with an antibiotic bound (using the same colours as the LEGO to make it obvious). Under the hood this is VMD but I coded a simplified GUI to make it easier to use. Using the surface representation as shown, by turning the antibiotic on and off, you can clearly see how well it fits in the protein and so how a small change would be sufficient to disrupt the binding.

vmd-1

Overall it went well and we had a constant stream of people at our stall. What struck me was how some of the children were genuinely fascinated; I even turned around at one point to find a 9 year old rotating the protein on my laptop. You could talk to kids like this and (try to) explain concepts way beyond the national curriculum (like atomic theory and molecules). We had some mini GiantMicrobes – the “superbug” MRSA with its cape was a favourite. If you gave one of these to the kids who were very interested they loved it, and, I hope, may have lit the touch paper for an interest in science.

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